Research
• MacKenzie DJ, Robertson NA, Rather MI, Adams PD (2020) DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. iScience 23(2): 100838. doi: 10.1016/j.isci.2020.100838. The paper highlights that DNMT3b does not cooperate with BRAF to induce senescence by-pass in CRC, though the mice come down quite early due to high tumor burden when DNMT3B is induced in BRAFV600E mutant mice. Impact factor= 4.4
• Rai TS, Glass M, Cole JJ, Rather MI et at. (2017) Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Res. The paper highlights how a histone chaperone (previously shown lack of it leads to histone loss in senescent cells and cause cancer) contributes to innate immunity against viral infection. Impact factor=11.5
• Cole JJ*, Robertson JN*, Rather MI et al. (2017) Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. * co-1st . Genome Biology. The main outcome of this study is to highlight the role of small molecule epigenetic regulators, fasting (or caloric restriction) and catabolism inhibitors (like Rapamycin) in healthy ageing. Impact factor=10.8
• Kapoor S, Shah MH, Singh N, Rather MI et al. (2016) Genetic Analysis of PLA2G6 in 22 Indian Families with Infantile Neuroaxonal Dystrophy, Atypical Late-Onset Neuroaxonal Dystrophy and Dystonia Parkinsonism Complex. PLoS One. 2016 May-2nd Author. Impact factor=2.7 • Pradhan SA, Rather MI, Tiwari A, Bhat VK, Kumar A. Evidence that TSC2 acts as a transcription factor and binds to and represses the promoter of Epiregulin. Nucleic Acids Res. 2014 Jun. Co-1st author. Impact factor=11.5
• Rather MI, Shivananda S. Swamy, Kodaganur S. Gopinath, and Arun Kumar (2014). Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by WT1 promotes cell proliferation: implication for cancer therapeutics. J. Biol. Chem. 289, 968-976 Impact factor=4.2
• Rather MI, Shivananda S. Swamy, Kodaganur S. Gopinath, and Arun Kumar. (Jan 2013) Oncogenic microRNA-155 downregulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: Implications for cancer therapeutics. J. Biol. Chem.288, 608–618. Impact factor=4.2
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